A firm nodule develops from beneath the nail bed. They may also complain of stiffness, especially near the elbows, forearms, and hips. The lesions are caused by separation of a cartilage fragment from the epiphyseal growth plate which herniates through the periosteum surrounding the growth plate. Jump to section: Disease Summary . Hereditary Multiple Osteochondromas (HM Exostoses) NGS Panel Hereditary multiple exostoses (HME or MHE), also known as diaphyseal aclasis, is a rare medical condition in which multiple bony spurs or lumps (also known as exostoses, or osteochondromas) develop on the bones of a child.HME is synonymous with multiple hereditary exostoses and multiple osteochondromatosis, which is the preferred term used by the World Health Organization. Exostosis & Pseudopseudohypoparathyroidism Symptom Checker: Possible causes include Pseudohypoparathyroidism. Multiple Hereditary Exostosis - Stanford Children's Health The number of osteochondromas and the bones on which they are located vary greatly among affected individuals. . Osteochondromas are benign chondrogenic lesions derived from aberrant cartilage from the perichondral ring that may take the form of solitary osteochondroma, or Multiple Hereditary Exostosis. Introduction. Bumps near the knees can make it hard to walk or run. Two EXT genes account for 90% of the lesions. Hereditary Multiple Exostosis Treatment - Hopkins Medicine Alternative Names for Multiple Hereditary Exostoses1,5,6 The following synonyms for multiple heredity exostoses often are used in practice and in the literature: Chondral osteogenic dysplasia of direction Chondral osteoma Deforming chondrodysplasia Diaphyseal aclasis (multiple hereditary) Dyschondroplasia Exostosing disease Exostotic dysplasia EXT Hereditary multiple exostosis | Radiology Case | Radiopaedia.org Hereditary multiple osteochondromas, also known as hereditary multiple exostoses, is a disorder characterized by the development of multiple benign osteocartilaginous masses in relation to the ends of long bones of the lower limbs such as the femurs and tibias and of the upper limbs such as the humeri and forearm bones. Hereditary multiple exostosis- Clinical cases, top doctors Changes indicative of disease are seen as alterations in the oral mucosa lining the mouth . Hereditary multiple exostoses (HME) is an autosomal dominant disorder in which multiple exostoses, or osteochondromas, form. Blood (two 4ml EDTA tubes, lavender top) or Extracted DNA (3ug in EB buffer) or Buccal Swab or Saliva (kits available upon request) The bumps can be painful.