OBJECTIVES To compare the effect of equal doses of oral calcitriol and alfacalcidol on intact parathyroid hormone concentrations (iPTH) in the treatment of secondary… Expand This suggests that calcitriol may. Oral calcitriol versus oral alfacalcidol for the treatment of secondary ... vitamin D or calcitriol is consequently deficient in CKD and also contribute to PTH elevation [2]. Beyond Calcium Absorption. Preliminary evidence is provided that equal doses of oral alfacalcidol and calcitriol may demonstrate differences in iPTH suppression during the first six weeks in dialysis patients treated for secondary hyperparathyroidism. In this investigator-initiated multicenter randomized clinical trial, we originally intended two crossover study periods with a washout interval in 86 . Few trials have tested the effect of bis- . BACKGROUND Secondary hyperparathyroidism is a common complication in patients with chronic kidney disease and treatment with vitamin D analogues is a mainstay of therapy. Over-the-counter vitamin D needs to be activated by the kidneys in order to work in the body. This suggests that calcitriol may be the optimal active vitamin D 3 for the treatment of SHPT in chronic hemodialysis patients. The aim of the current study was to compare the effects of cholecalciferol at 800 IU per day and calcitriol at 0.25 μg per day on calcium metabolism and bone turnover in Chinese postmenopausal women who are vitamin D insufficient. Parathyroid hormone (PTH), serum calcium and serum phosphorus levels were compared pre- and post-conversion using paired Student's t tests. Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D 3, 1,25-dihydroxyvitamin D 3.It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. Alfacalcidol - an overview | ScienceDirect Topics Conclusion: Alfacalcidol can be used to control secondary hyperparathyroidism at doses of 1.5-2.0 times that of calcitriol. Alfacalcidol: Uses, Interactions, Mechanism of Action - DrugBank PDF RESEARCH ARTICLE Open Access Comparison of oral and intravenous ... @article{Rauscher2016ConversionOO, title={Conversion of oral alfacalcidol to oral calcitriol in the treatment of secondary hyperparathyroidism in chronic hemodialysis patients}, author={Sandrine Rauscher and Jean-Philippe Lafrance and Vincent Pichette and Robert Z Bell and Katherine Desforges and Laurence Lepage and Georges Ouellet and Denis .